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Meet Sky Foundation's Newest Researchers

Sky Foundation has awarded seed grants to five researchers at four Midwest institutions, each chasing a new idea against pancreatic cancer.

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Annie Dalton
October 30, 2026 · 5 min read
Meet Sky Foundation's Newest Researchers

Sky Foundation is proud to welcome five new researchers to the Sky family. Each has received a Sky Foundation seed grant to pursue a new idea in pancreatic cancer research: the early work that national funders are often not yet ready to support.

The grants span four institutions: Michigan State University, the University of Michigan, the Medical College of Wisconsin and the University of Minnesota. Three of the five work right here in Michigan.

Their projects take on some of the hardest questions in the disease: why different KRAS mutations behave differently, how pancreatic tumors adapt to low oxygen, how liver injury after chemotherapy can fuel the cancer's spread, and which drug combinations could reprogram the cancer's metabolism.

Meet the researchers

Jonathan Diedrich, PhD
Michigan State University

Jonathan Diedrich, PhD

Assistant Professor, Department of Pharmacology and Toxicology, College of Osteopathic Medicine
Michigan State University
The project
Allele-Specific Oncogenic Rewiring: A Multi-Omic Landscape of KRAS Variant Biology in Pancreatic Cancer

KRAS mutations drive the majority of pancreatic cancers, but different KRAS mutations are often treated as if they were the same. Current evidence suggests they are not. Dr. Diedrich's laboratory uses pancreatic cancer cells engineered to be genetically identical except for their specific KRAS mutation. With this model, the team can see how each mutation sends its own signals and reshapes gene activity, metabolism, cell behavior, and morphology.

In this project, the lab will combine multi-omic and high-content imaging approaches to build a side-by-side picture of how each KRAS mutation rewires pancreatic cancer cells. These approaches profile genome accessibility (ATAC-seq), gene expression (RNA-seq), cell shape and structure (Cell Painting), and nutrient use (¹³C-glucose tracing and Seahorse XF analysis). The goal is to find weak points specific to each mutation that could be targeted with existing or new drugs. As KRAS inhibitors and other precision treatments advance, this work aims to help match each patient with the therapy most likely to work against their tumor's mutation.

About Dr. Diedrich

Dr. Diedrich earned his BS in Zoology from Michigan State University and his PhD in Cancer Biology from Wayne State University, where he studied the links between obesity, metabolism, and cancer. He then completed postdoctoral training at St. Jude Children's Research Hospital. There, he focused on pharmacogenomics, integrating multi-omic approaches and functional CRISPR screens to identify genes and regulatory elements associated with drug response and resistance in pediatric acute lymphoblastic leukemia. His work helped show that genetically distinct subtypes of leukemia are wired differently at the level of chromatin and gene regulation, and that these differences can shape how patients respond to treatment.

He is currently an Assistant Professor at Michigan State University, where he is applying this expertise to pancreatic cancer. He is building a multi-omic and functional atlas of KRAS mutations in pancreatic cancer in collaboration with Dr. Thomas McFall of the Medical College of Wisconsin, a close friend from his graduate school cohort at Wayne State. Together, they aim to understand how each mutation changes cancer cell behavior and to find mutation-specific therapeutic vulnerabilities. Having grown up in Michigan, Dr. Diedrich is proud to return to his alma mater and is driven by a commitment to ensuring that advances in precision medicine reach every patient with pancreatic cancer.

Brittany Hartwell, PhD
University of Minnesota

Brittany Hartwell, PhD

Assistant Professor, Department of Biomedical Engineering
University of Minnesota
About Dr. Hartwell

Dr. Brittany Hartwell is an Assistant Professor of Biomedical Engineering at the University of Minnesota. Her lab's research in immunoengineering combines perspectives from biomolecular engineering, drug delivery, and immunology to develop molecular platforms that can target specific cells and tissues of the immune system to direct the immune response, with a particular focus on targeting and "tuning" mucosal immunity. This work has broad applications ranging from the development of antigen-specific immunotherapies that induce immune tolerance against autoimmune and chronic inflammatory diseases, to development of targeted vaccines that activate immune protection against cancer and infectious diseases.

For this work she was selected as one of four researchers worldwide to receive a 2022 Michelson Prize, awarded to early career investigators in human immunology and vaccine research. She also received a PhRMA Foundation Faculty Starter Grant in Drug Delivery in 2025. Prior to starting her faculty position at the University of Minnesota in fall 2021, she completed postdoctoral training with Dr. Darrell Irvine at Massachusetts Institute of Technology (2021) in immunoengineering, where she worked on developing targeted mucosal vaccines against HIV and COVID. Hartwell received her PhD in biomolecular engineering with Dr. Cory Berkland at the University of Kansas (2016), where she worked on developing multivalent antigen-specific immunotherapy platforms for autoimmune diseases like multiple sclerosis. She received her B.S. in chemical and biological engineering from Iowa State University (2011).

Priyanga Jayakrishnan, PhD
Medical College of Wisconsin

Priyanga Jayakrishnan, PhD

Postdoctoral Fellow, Department of Surgery
Medical College of Wisconsin
The project
The Role of Midkine in Pancreatic Cancer Initiation and Progression to Liver Metastasis

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a strong propensity for liver metastasis. Previous studies demonstrated that chemotherapy-induced liver injury can create a pro-metastatic microenvironment that accelerates pancreatic cancer liver metastasis. This work investigates the molecular signals generated by chemotherapy-associated liver injury that support metastatic tumor growth, with the goal of identifying therapeutic strategies to prevent disease progression and recurrence.

Single-cell RNA sequencing revealed increased Midkine (MDK) signaling from hepatocytes to pancreatic cancer cells after chemotherapy in mice with accelerated liver metastasis. MDK is not restricted to hepatocytes: cancer-associated fibroblasts and pancreatic cancer cells also express it, suggesting that both paracrine and autocrine signaling may contribute to pancreatic cancer progression and liver metastasis. The team has also identified multiple MDK transcripts specific to pancreatic cancer cells and liver metastases, raising the possibility that isoform-specific MDK signaling contributes to tumor progression and metastatic behavior.

The project will define how tumor- and microenvironment-derived MDK, including cancer-associated MDK isoforms, contributes to pancreatic cancer progression, therapy response, and the establishment of liver metastasis. Ultimately, the aim is to determine whether targeting MDK signaling can limit pancreatic cancer progression and metastatic recurrence.

About Dr. Jayakrishnan

Priyanga Jayakrishnan completed her Ph.D. in India, where she investigated the molecular mechanisms underlying centrosomal abnormalities and genomic instability in breast cancer. She started as a postdoctoral fellow in the Lytle Lab in 2024, where her research has expanded to understand how therapy-induced tissue injury and tumor-microenvironment interactions influence cancer progression and metastasis.

Her work focuses on both breast and pancreatic cancer and integrates mouse models, CRISPR-based approaches, organoid systems, and single-cell and bulk transcriptomics. Her current research investigates how chemotherapy-induced injury alters mammary epithelial cell states and may contribute to the development of second primary breast cancer. In pancreatic cancer, she studies how tumor- and microenvironment-derived signaling promotes tumor progression and liver metastasis.

Jeffrey Klomp, PhD
Michigan State University

Jeffrey Klomp, PhD

Assistant Professor, Department of Medicine, College of Human Medicine
Michigan State University
The project
Targeting Hypoxia-Driven Drug Vulnerabilities in Pancreatic Cancer Through Repurposing of Clinically Actionable Compounds

This project aims to find new treatment options for pancreatic cancer by taking advantage of a unique weakness caused by the tumor's low-oxygen environment. Pancreatic tumors often grow in areas with very little oxygen, which forces cancer cells to adapt and rely on different survival pathways. Dr. Klomp's research has shown that these low-oxygen conditions change how pancreatic cancer cells respond to important cancer-driving signals such as through KRAS and ERK, potentially creating new vulnerabilities that can be targeted with drugs.

The lab will test a library of existing clinically relevant medicines to identify compounds that are especially effective against cancer cells growing under low-oxygen conditions or that improve the effectiveness of KRAS-targeted therapies. Because many of these drugs are already approved or have well-established safety profiles, promising discoveries could be advanced more rapidly toward patient care. Ultimately, this work seeks to uncover new treatment strategies for one of the deadliest cancers and improve outcomes for patients with pancreatic cancer.

About Dr. Klomp

Dr. Jeffrey Klomp is an assistant professor with the Department of Medicine, within the Michigan State University College of Human Medicine. He is interested in systems biology of cancer adaptations, focusing on the frequently mutated oncogene KRAS and a critical signaling enzyme, ERK. His laboratory is located within the MSU biomedical research complex in Grand Rapids, Michigan.

Dr. Klomp is a Michigan native and has trained at the Van Andel Research Institute, University of Chicago, and University of Illinois. His most recent work was with the University of North Carolina, where he produced pivotal research under the mentorship of Dr. Channing Der, a pioneer in the discoveries of the human RAS gene. He currently collaborates with labs at MSU, including that of Dr. Jennifer Klomp, as well as members of the HFH+MSU Pancreatic Cancer Center.

Jamie Mills, MD, PhD
University of Michigan

Jamie Mills, MD, PhD

Department of Internal Medicine, Division of Hematology & Oncology
University of Michigan
The project
Understanding Metabolic Reprogramming in PDAC Through Dual Inhibition of KRAS and BRD4

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers, with a 5-year survival rate of only 13% and an urgent need for more effective therapeutic strategies. This project focuses on the protein BRD4, which is implicated in regulating cancer growth and metabolism. The team will test combinations of inhibitors for BRD4 and other key PDAC regulatory pathways and analyze the effect these combinations have on metabolic and epigenetic changes in the cancer cells and mouse models of PDAC.

This study will establish a foundation for future studies that will test these therapeutic combinations in clinical trials, with the goal of improving patient outcomes in this difficult-to-treat malignancy.

About Dr. Mills

Dr. Mills is from the San Francisco Bay Area and completed her undergraduate studies at California State University, Chico. She then matriculated to the Medical University of South Carolina in Charleston, earning her MD and PhD in cancer biology.

Dr. Mills completed her Residency in Internal Medicine and Fellowship in Hematology & Oncology at the University of Michigan, where she is now faculty specializing in the treatment of pancreatic and other GI malignancies. She is part of a research team studying various aspects of pancreatic cancer biology with the goal of translating laboratory findings efficiently into clinical trials, where discoveries can benefit patients with pancreatic cancer.

Why this matters for Sky

Seed grants give promising scientists the time and early data to prove an idea, so they can compete for the larger national grants that carry it toward patients. Every gift to Sky helps fund the next one.

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