Rafael A. Fridman, PhD
Wayne State University, Karmanos Cancer Institute, Detroit
Fridman is a scientific member of the Tumor and Microenvironment Program at the Karmanos Cancer Institute and a professor in the Department of Pathology at Wayne State University’s School of Medicine. Fridman’s research, in collaboration with Howard Crawford (above), is to investigate the role of fibrosis in pancreatic cancer with a focus on cancer cell-collagen interactions. The project is expected to explain the regulation and role of the Discoidin Domain Receptors (DDRs).
In addition, the study is expected to uncover the likely major contribution of collagen to tumor behavior and progression. Fibrosis and the associated collagen have been shown to act as critical barriers to delivery of therapeutic drugs.