Sky Foundation, Inc. — Accelerating progress in pancreatic cancer
Patient Resources
Article 05 of 056 min read

Glossary & Terms

Understanding medical terms can make the treatment journey less overwhelming. Plain-language explanations of important terms, plus the basics of types, stages, surgery and symptoms — and where to go next.

Glossary & Terms

Glossary of key terms

Adenocarcinoma. The most common type of pancreatic cancer, beginning in the ducts that carry digestive enzymes.
Biopsy. A procedure where a small tissue sample is removed and examined under a microscope to confirm the presence of cancer.
CA 19-9. A blood test measuring a protein sometimes elevated in pancreatic cancer. Not used alone for diagnosis, but it can help track treatment response.
Chemotherapy. Drugs that kill cancer cells throughout the body, often given in cycles.
Endoscopic ultrasound (EUS). A procedure using an endoscope with ultrasound to obtain detailed images and tissue samples of the pancreas.
Metastasis. The spread of cancer cells from the original tumor to other parts of the body, such as the liver or lungs.
Neoadjuvant therapy. Treatment — usually chemotherapy or radiation — given before surgery to shrink a tumor.
Palliative care. Specialized medical care focused on managing symptoms and improving quality of life, provided alongside cancer treatment.
Resectable. A tumor that can be removed completely with surgery.
Whipple procedure (pancreaticoduodenectomy). A complex surgery to remove the head of the pancreas, part of the stomach, the duodenum, bile duct and gallbladder.
Source
National Cancer Institute — Pancreatic cancer →
Source
National Cancer Institute — Palliative care →

Types of pancreatic cancer

Pancreatic cancer can start in the exocrine cells, which make digestive juices, or in the endocrine cells, which make hormones. About 95% of pancreatic cancers begin in exocrine cells, and the most common type, pancreatic ductal adenocarcinoma (PDAC), makes up about 90% of cases. Cancers that form in endocrine cells are called pancreatic neuroendocrine tumors, or islet cell tumors. They are much less common and are treated differently.

Source
National Cancer Institute — What is pancreatic cancer? →

Stages of pancreatic cancer

Stage 0. Abnormal cells are found in the lining of the pancreas and have not spread beyond it.
Stage I. Cancer is found in the pancreas only.
Stage II. The tumor is larger than 4 cm, or cancer has spread to one to three nearby lymph nodes.
Stage III. Cancer has spread to four or more nearby lymph nodes, and may have reached major blood vessels near the pancreas.
Stage IV. Cancer has spread to other parts of the body, such as the liver, lungs or the lining of the abdomen.

Doctors also group pancreatic cancer by whether surgery can remove it: resectable (it can be completely removed), borderline resectable (it has grown into a major blood vessel or nearby tissue) and unresectable (locally advanced or metastatic cancer that cannot be removed with surgery).

Source
National Cancer Institute — Pancreatic cancer stages →

Surgical options

Surgery gives the best chance of long-term survival when it can completely remove the tumor, but pancreatic cancer is often found after that is possible. Your doctor will weigh the risks and benefits with you.

Whipple procedure (pancreaticoduodenectomy). For tumors in the head of the pancreas. Removes the head of the pancreas, the gallbladder, part of the small intestine, part of the bile duct and part of the stomach.
Distal pancreatectomy. For tumors in the body and tail of the pancreas. Removes the body and tail, and sometimes the spleen.
Palliative procedures. A stent placed in a blocked bile duct or duodenum, or a gastric bypass when a stent is not possible, to relieve symptoms. These are not meant to cure the cancer.
Source
National Cancer Institute — Pancreatic cancer treatment →

Symptoms of pancreatic cancer

Pancreatic cancer usually has no early signs, which makes it hard to find early; symptoms often begin after the cancer has spread. As it grows, it can cause:

Pain in the upper or middle abdomen and back
Jaundice — yellowing of the skin and whites of the eyes, light-colored stools, dark urine and itching
Weight loss for no known reason, and loss of appetite
Fatigue
Gas or bloating, nausea and vomiting
Swelling in the legs
An enlarged gallbladder or liver
Source
National Cancer Institute — Pancreatic cancer symptoms →
Sky Foundation
Know the signs — Sky Foundation →

Questions to ask your doctor

Walking in with written questions helps you get the most from every appointment. Sky Doctor Questions gathers the questions patients told us they wished they had asked — 112 questions across 10 specialists — ready to print by doctor or all at once.

Sky Foundation
Browse Sky Doctor Questions →

Where can I find clinical trials?

Sky Foundation recommends TriCan Health, which matches your diagnosis to open trials and lets you filter by location, stage of cancer, type of treatment and enrollment status.

Source
Browse trials on TriCan Health →

Key takeaway

A strong understanding of terms and treatment basics helps patients and caregivers feel informed and prepared. Asking questions, keeping notes and using trusted resources will empower you to play an active role in your care plan.

GIVE NOW