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University Of Michigan Lab Work

Passion for Change Runs In The Family

The passion to find a cure for pancreatic cancer runs in the family! Sheila’s granddaughter, Samantha Kasselman works in the Frankel Lab at the University of Michigan Rogel Cancer Center studying the role of inflammation in pancreas cancer induction. She recently presented at the Department of Surgery Moses Gunn Research Conference, and did a fantastic job! It is so important to keep this passion running through generations so that we can continue to find breakthrough research and fight this disease.

Dr. Timothy Frankel and his team in his cancer research lab, Thursday, January 25, 2018.

University of Michigan | Howard Crawford Laboratories

Immunotherapy

The Pasca di Magliano, Lyssiotis, Frankel and Crawford laboratories at the University of Michigan have teamed up to devise ways to make immunotherapy effective in fighting pancreatic cancer. Dr. Pasca di Magliano has discovered that macrophages, a specialized inflammatory cell, are the cells primarily responsible for establishing the immune suppressed environment by both sending signals to immune cells to ignore the tumor and then signaling to the tumor cells to have them express high levels of PD-L1.

In turn, the tumor cells instruct the macrophages to also make PD-L1. In an attempt to disrupt this cycle, Dr. Crawford has identified one of the primary molecules the macrophages use to turn on tumor cell PD-L1, known as HBEGF. Meanwhile, Dr. Lyssiotis has found that tumor cell metabolites are responsible for telling the macrophages to make PD-L1. With this knowledge in hand, Dr. Frankel, a surgeon who specializes in immunotherapy research, is involved in translating these observations to the clinic, combining immune checkpoint inhibitors with therapies to disrupt the cellular crosstalk responsible for establishing the immunosuppressive environment in preclinical models of human pancreatic cancer.

Immunotherapy Team Members

Marina Pasca di Magliano, PhD

Costas Lyssiotis, Phs

Timothy Frankel, MD