Passion for Change Runs In The Family
The passion to find a cure for pancreatic cancer runs in the family! Sheila’s granddaughter, Samantha Kasselman works in the Frankel Lab at the University of Michigan Rogel Cancer Center studying the role of inflammation in pancreas cancer induction. She recently presented at the Department of Surgery Moses Gunn Research Conference, and did a fantastic job! It is so important to keep this passion running through generations so that we can continue to find breakthrough research and fight this disease.
University of Michigan | Howard Crawford Laboratories
In turn, the tumor cells instruct the macrophages to also make PD-L1. In an attempt to disrupt this cycle, Dr. Crawford has identified one of the primary molecules the macrophages use to turn on tumor cell PD-L1, known as HBEGF. Meanwhile, Dr. Lyssiotis has found that tumor cell metabolites are responsible for telling the macrophages to make PD-L1. With this knowledge in hand, Dr. Frankel, a surgeon who specializes in immunotherapy research, is involved in translating these observations to the clinic, combining immune checkpoint inhibitors with therapies to disrupt the cellular crosstalk responsible for establishing the immunosuppressive environment in preclinical models of human pancreatic cancer.
Immunotherapy Team Members
Marina Pasca di Magliano, PhD
Costas Lyssiotis, Phs
Timothy Frankel, MD